Amino Acid Variation at Hemagglutinin Position 193 Impacts the Properties of H9N2 Avian Influenza VirusArticle Published on 2023-02-282023-06-22 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] antigenicity H9N2 avian influenza virus HA variation position 193 receptor Replication Transmission. [DOI] 10.1128/jvi.01379-22 PMC 바로가기
Key Factors for “Fishing” NTCP as a Functional Receptor for HBV and HDVReview Published on 2023-02-122023-06-12 Journal: Viruses [Category] B형 간염, [키워드] Cross-linking HBV HDV NTCP PreS1 receptor viral entry. [DOI] 10.3390/v15020512 PMC 바로가기 [Article Type] Review
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathwayArticle Published on 2023-01-302022-11-16 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, 치료기술, [키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α Toll-like receptor 4. treated Treatment were assessed were measured [DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2Article Published on 2023-01-012022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, [키워드] Accuracy ACE2 acute respiratory syndrome addition antibody biosensor biosensors caused Cell cells complex coronavirus coronavirus disease COVID-19 detect detection Diagnosis drug evaluated gold standard Health increase Interaction modulate Mutation Novel coronavirus pandemic Prevent receptor RT-PCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. the spike protein time-consuming variants Variation virus virus mutations [DOI] 10.1016/j.talanta.2022.123813 PMC 바로가기
Virological, pathological, and glycovirological investigations of an Ezo red fox and a tanuki naturally infected with H5N1 high pathogenicity avian influenza viruses in Hokkaido, JapanArticle Published on 2023-01-012023-06-21 Journal: Virology [Category] 조류인플루엔자, [키워드] Ezo red fox high pathogenicity avian influenza virus Histopathology receptor Tanuki. [DOI] 10.1016/j.virol.2022.11.008 PMC 바로가기
Detection of anti-NMDA receptor antibodies following BBIBP-CorV COVID-19 vaccination in a rituximab-treated person with multiple sclerosis presenting with manifestations of an acute relapse급성 재발의 징후를 나타내는 다발성 경화증을 가진 리툭시맙으로 치료받은 사람에서 BBIBP-CorV COVID-19 백신 접종 후 항-NMDA 수용체 항체 검출Article Published on 2022-12-312022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, 진단, [키워드] added administration Anti-N-methyl-D-aspartate receptor Anti-N-Methyl-d-Aspartate receptor antibodies anti-NMDAR antibodies antibody ataxic Autoimmune Autoimmune encephalitis Babinski sign BBIBP-CorV benefit Case report clinician corticosteroid pulse COVID-19 COVID-19 vaccination CSF analysis detection early diagnosis Encephalitis initiated manifestation MRI multiple sclerosis multiple sclerosis. Neurological symptom NMDAR Patient performed Physical examination plaques positive presenting receiving receptor second dose serum Sinopharm Symptoms tested therapy Vaccines worsening [DOI] 10.1080/21645515.2022.2033540 PMC 바로가기 [Article Type] Article
ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering. Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencingSARS-CoV-2 감염 또는 단일 세포 V(D)J 시퀀싱을 통한 백신 접종에 의해 유도된 비교 글로벌 B 세포 수용체 레퍼토리 차이Article Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] antibody B cell BBIBP-CorV BCR BCR repertoire change Comparative COVID-19 COVID-19 recovered patient dynamic FIVE group groups Guidance healthy healthy donor humoral immune response IGHV3-23 IGHV3-33 inactivated Inactivated vaccine Infection performed Precision proportion receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine Sequencing single-cell Single-cell RNA sequencing single-cell RNA sequencing. subject subjects the SARS-CoV-2 treated vaccination Vaccine [DOI] 10.1080/22221751.2022.2105261 PMC 바로가기 [Article Type] Article
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
COVID-19 and inflammatory bowel disease crosstalk: From emerging association to clinical proposalArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] abdominal pain ACE2 acute respiratory syndrome addition association Autoimmune bowel Care caused coronavirus coronavirus disease COVID-19 COVID-19 epidemic diarrhea disease downregulated enzyme Epidemic etiology exacerbate expressed feasibility Genetic IBD IL-17 Imbalance immune activation immunosuppressive drug increase induce Infection Inflammatory Inflammatory bowel disease inflammatory bowel disease. inflammatory disease Inflammatory response intestinal intestinal inflammation intestine lung mechanism nonspecific overlapping pathway Patient patients Pneumonia progression protective factor receptor Research respiratory inflammation risk risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection Symptom systemic symptom the cytokine storm the SARS-CoV-2 Treatment upregulated vaccination [DOI] 10.1002/jmv.28067 PMC 바로가기